Our Company Press Release How It Works FAQ's Before & After Research Order now EXPENSIVE IS NOT ALWAYS BETTER A consumers guide to glutathione supplementation It is hard not to comment on some myths and lies that are being propagated by some glutathione distributors. We would have let it pass seeing the absurdity of some of those lies but then we feel compelled to let the consumers know a few simple truths to give them a semblance of protection from unscrupulous distributors who continue to mislead them into buying expensive but ineffective products. Fact: GLUTATHIONE, WHETHER REDUCED, OXIDIZED OR ANY OTHER FORM IS NOT EFFICIENTLY ABSORBED WHEN TAKEN ORALLY Time and again we have been trying to impart this simple fact to the consumers. You only absorb less than half of what you take orally. A study even shows that a single massive oral 3000mg dose failed to raise the body's inherent weakness of glutathione is due to its unstable bonded, tri-peptide form which makes it susceptible to attack by stomach enzymes. Most of it is destroyed once it enters the stomach and only a few remaining gets absorbed by our system. This is how they will mislead you: They claim that their product is reduced and is much better absorbed. NOT TRUE. Regardless of its form, fact remains that it can't absorbed through oral administration. They will show you a study or an internet link that will say that the reduced form is ideal but they will not tell you that it is ideal through intravenous administration. Always check the whether it's ideal when taken ORALLY. Tip: Go search for facts yourself. Even wikipedia.org has information on this. Fact: N-ACETYLCYSTEINE (NAC) IS FAR BETTER IN RAISING THE BODY'S LEVELS THAN GLUTATHIONE ITSELF. Dr. Robert Atkins of the Atkin's be discussed apart from NAC and that NAC raises the body's level something that oral supplements of glutathione itself cannot do. This is due to the fact that NAC is considered to be the best glutathione precursor. The term "precursor" is applied to an inactive substance converted to an active one (such as an enzyme, vitamin, or hormone). This is how they will mislead you. Silly as it may sound, they will tell you that glutathione is better known as a skin whitener. Complete fact should be that one of the common benefits of ELEVATED GLUTATHIONE LEVELS IN THE BODY is that the skin will become fairer and look younger. Glutathione may be known to lighten the skin but taking it orally to lighten the skin is a whole different thing altogether. It simply just can't a great injustice to peddle around the idea of raising the body's levels as a mere skin whitening method. They will go to the extent of calling NAC cheap. Ok then by that argument, would you rather go for a much expensive but ineffective supplement or a more affordable and effective one? Besides, if it were really that cheap, why didn't brands have it in their product in the first place? Tip: This fact can be easily confirmed by looking up glutathione supplementation on the internet. Fact: FREE FORM AMINO ACID COMPONENTS OF GLUTATHIONE IS A MUCH BETTER ALTERNATIVE TO BONDED GLUTATHIONE Glutathione is a tri-peptide thiol consisting of three amino acids: l-cysteine, glycine and glutamic acid. The first fact shows that only a small amount of this is remains and gets to the small intestines. Once it gets there it is absorbed through the intestinal epithelial cells where it still needs to get broken down into the three free form amino acids before it gets distributed into the entire body. Free form amino acid components of glutathione is much easier absorbed by the body because it withstands the attack of stomach enzymes and passes easily through the intestinal epithelial cells straight into our system. Serious athletes know this and prefer free form aminos than thiols/polypeptides. The components glycine and glutamic acid are staples in the athletes amino acid supplement. This is how they will mislead you: Again they will call the 3 amino acid blend cheap. In that case would you choose a more expensive but ineffective blend? They might try and scare you into thinking that partaking free form amino acid is dangerous but nothing could be further from the truth. Tip: Nursing students just need to check their books on anatomy and physiology and open the part on digestive system, protein and amino acid transport (Essentials on Anatomy and Physiology). Also check out this study conducted by the University of Colorado comparing free-form and tri-peptide absorption. http://www.vivo.colostate.edu/hbooks/pathphys/digestion/smallgut/absorb_aacids.html THE KYUSOKU BIHAKU ADVANTAGE The Kyusoku Bihaku blend takes all these to heart by giving consumers the best formulation available. KB has all three free-form amino acid components l-cysteine, glycine and glutamic acid. Apart from this, KB is formulated with NAC and Cystine, which is another good glutathione precursor. To further complement this one-of-a-kind blend, KB has included a separate bottle of Vitamin C Rosehips. Vitamin C is a great help in amino acid absorption because it aids in its synthesis. KB is priced at $ 40at Mercury Drug stores and other outlets nationwide. KB reveals glutathione activating formula 08022008 After months of keeping its exact glutathione supplement blend secret, Kyusoku Bihaku or KB finally reveals its formulation. Alex Mirador, company president, said that this move will hopefully avoid confusion in terminologies, testing method and controversies in the future. He said that although KB started out as a 30capsule bottle of 500mg/cap reduced glutathione, the company continuously reformulated to improve its blend to its present formulation to give the best products to its loyal consumers. "The reason for this constant improvement," he said, "is the fact that glutathione be it reduced or any other form, is very inefficient and wasteful when the supplement is taken orally. Less than half of it is absorbed in the gastrointestinal tract and the rest of it goes to waste." When glutathione reaches the stomach, Mirador explained that it is immediately attacked and most of it is destroyed by enzymes. The remaining glutathione that survives the onslaught is absorbed through the intestinal epithelial cells where it still needs to be broken down into its free form amino acid state before it gets distributed throughout the body. He added that studies show that even a massive single oral dose of 3,000mg of glutathione is not enough to raise the body's levels to a clinically beneficial extent. Reduced and oxidized glutathione is a tripeptide thiol consisting of the amino acids l-cysteine, glycine and glutamic acid. The three amino acids are bonded by protein. This bond makes glutathione unstable and thus ineffective for oral supplementation. Latest research show that taking the free-form components of glutathione is far better than taking glutathione itself because it is bioavailable, withstands the attack of enzymes and is directly absorbed straight into our system. The KB formulation takes this latest study to heart. Each KB capsule has equal amounts unbonded glutathione components l-cysteine, glycine and glutamic acid. Apart from the glutathione components, KB also has N-Acetylcysteine (NAC) in its blend. Experts agree that NAC, a glutathione precursor, is the best glutathione booster available today. In his book Vita Nutrient Solutions, Dr. Robert Atkins of the Atkins Diet fame said, "Glutathione cannot be discussed apart from NAC. NAC raises the body's glutathione levels something that oral supplements of glutathione itself cannot do." "To cap all these innovations in oral glutathione supplementation, KB comes as a 2 bottle set with the bottle being Vitamin C Rosehips," Mirador said. "Vitamin C increases the effectiveness of amino acid supplements by aiding in its synthesis." Mirador opined that the KB formulation proves that the product has been well thought out, incorporating the latest developments in oral glutathione supplements and it is not just another run-of-the-mill copycat product. "KB should have been spared from the glutathione controversy last May," Mirador lamented. "Kyusoku Bihaku should have been tested using a different method because of its unique composition." He admitted that although their sales were affected by the issue, most of their clients remained loyal because majority of them are converts from other brands and have proven for themselves that KB is a better product. "Kyusoku Bihaku is arguably the best oral supplement out there and I am assuring our loyal clients that we will continue to improve or our formulation to deliver the best results to them," Mirador said in closing. Kyusoku Bihaku or KB is priced at Php1,500.00 per set and is available at all leading drugstores nationwide. For comments and suggestions call or text KB hotlines +639284104227, 02 7292580, 0917 8005836, 4964321, 6356982 or log on to www.ilovekb.com.Look for aileen aycardo ADVISORY We would like to inform everyone that the first Kyusoku Bihaku L-Glutathione (reduced) 500mg was introduced around 2005 through a different distributor with Yumei Mise Inc. After the contract with the distributor, ownership of the brand was turned over back to Yumei Mise. In keeping up with the latest developments and trends in oral glutathione supplementation, Kyusoku Bihaku (KB) regularly updates its formulation in order to deliver the best results to its clients. In one of the reformulations, the company threw in another bottle of separate vitamin C at no added cost because of the ability of the vitamin to aid in amino acid synthesis. The company's continued updates for better a formula is due to the inherent weakness of glutathione: whether reduced or any other form it can't be absorbed effectively through oral administration. Only less than 50% of the supplemental glutathione is absorbed through the gastrointestinal tract and the rest goes to waste. Some studies have even shown that a daily oral dose of 3,000mg showed no significant increase in a test subject's glutathione levels. As always, KB's latest formulation is the company's way of dealing with this glaring weakness of oral glutathione supplements. Experts are in agreement that N-acetylcysteine (NAC) is a far better oral supplement for elevating the body's glutathione levels than any other--even glutathione itself. NAC was recently added into the KB blend. A new study also shows better results when supplementing with components of glutathione in free form other than glutathione itself. Glutathione is a tripeptide thiol consisting of the amino acids l-cysteine, glycine and glutamic acid. Once the glutathione enters the stomach, digestive enzymes destroy a good part of it leaving a minimal amount to be absorbed in the small intestine. Once it gets there, the remaining glutathione is absorbed in the intestinal epithelial cells where it still needs to be broken down into amino acids before it gets distributed into the entire body. Latest study reveals that free form amino acids is much better absorbed because it withstands the attack of the stomach enzymes and passes easily through the epithelial cells and directly into our system. The latest formulation of KB takes this new study to heart and came out with the equal amounts of the unbonded free form glutathione components l-cysteine, glycine and glutamic acid. MORE KB INFORMATION: 1. What is the difference between the latest KB formulation in the market and the OLD KB. OLD KB - Formulation is L-Glutathione (reduced) 500mg NEW KB - The composition is made up of 3 free-form (unbonded) amino acids Glutamic, Glycine and Cysteine with N-Acetyl Cysteine and a separate Kyusoku Bihaku Vitamin C Rosehips. 2. When was this new formulation of KB applied with the Bureau of Food and Drugs. It was presented to the BFAD and was applied for NEW FORMULATION approval around February 2008. The CPR was released around APRIL 22, 2008, encoded around APRIL 28, 2008 and was received by our company around May 2008. However, we have made some recent corrections in the brand name and formulation both of which are being presented. At the same time we also applied for approval for our new packaging. 3. How many batches were released so far? Two batches were released so far. The first batch was recalled by the Yumei Mise because there were misprints and errors in the packaging. And replaced with the second batch, is the ym05091. (which is our first batch in the market) We would also like to inform the PUBLIC that due to the composition KB, the test that should be implemented is Gaschromatography oe EZ Assay Amino Kit Test (FYI: Reduced Glutathione for HPLC) The cost for this kind of comprehensive test ranges from 30,000 to 80,000 pesos. Also, our product is NOT REDUCED GLUTATHIONE but a composition of unbonded FREE FORM AMINO ACID (Glutamic acid, Glycine and Cysteine) plus N-Acetyl L-Cysteine. Most of the Glutathione that are in reduced form is indicated in their label. THIS STATEMENT IS BEING PRESENTED BY YUMEI MISE INC. This move aimed at not only minimizing confusion in terminologies and testing sytem, but to avoid further controversies as well. Oral glutathione made even better The latest research have shown that glutathione is the most potent antioxidant currently known to man. Some have called it the miracle cure all owing to its unparalleled inhibiting effect on free radicals which makes it a powerful weapon to combat a wide range of degenerative diseases. It has been shown not only to protect individual cells but also the tissues of the some of the major organs, including the skin against oxidant damage. This quality spurred the million-peso industry of oral glutathione in the country focusing on its ability to make the skin fairer and protect it from the ravages of ageing. With the burgeoning industry all the more getting bigger and more profitable, so-called experts connected to the industry have been too reluctant to boldly state one unmistakable fact: L-GLUTATHIONE (reduced in capsule form) IS POORLY ABSORBED ORALLY. Glutathione is a tri-peptide thiol consisting of three amino acids, Cysteine, Glutamic acid and Glycine while the Glutathione (free form) replacement is also consist of those three amino acids in single bond. When taken orally, l-cysteine loses 85% of its sulfur group (which becomes the active component of glutathione) during the digestion process. This means that less than half of the supplemental glutathione is absorbed through the digestive system. Without much explanation glutathione formulated with alpha lipoic acid (ALA) appeared on the market. ALA was supposed to be a glutathione booster. However, ALA is yet another another form of an unstable amino acid that it too, loses as much of its sulfur and sulfuhydryl components as the glutathione which leads to another unmistakable fact. Alpha-lipoic acid is practically useless as a glutathione booster. NAC (N-Acetyl L-Cysteine) NAC is an acetylated form of the amino acid L-Cysteine. It is in itself a powerful antioxidant and has been used to treat cystic fibrosis and acetaminophen overdose. Recent studies have consistently proven that NAC is the most powerful and most effective glutathione booster available today. NAC works by increasing the glutathione levels in the body. What makes NAC standout among the so-called glutathione boosters is that it is a stable compound with an ability to retain most of its sulfur and sulfuhydryl contents losing only 15% during the process of digestion. Some have even suggested that taking NAC is better than taking glutathione itself. However, this is only true in instances where an individual has depleted stores of glutathione in the body and needs supplementation to elevate it to healthy levels. NAC may boost the glutathione levels in the body, but it can only boost it to a certain extent which may still not be enough to maximize the true free radical inhibiting potential of glutathione. KYUSOKU BIHAKU L- Glutathione 500mg with NAC and Pure Rosehips Vitamin C Kyusoku Bihaku L-Glutathione pack comes formulated with the optimum dose of NAC to make the most of oral glutathione supplementation. The NAC processed into each of the quality KB glutathione capsule not only boosts the glutathione levels in the body but it also makes up for the glutathione components lost during the digestion process. More than just being the first to produce such a remarkable oral glutathione formulation, Kyusoku Bihaku also boasts of the fact that it is the only glutathione supplement in the country today made by its own manufacturing company. With factories located Korea and Japan, each KB capsule is produced under the strictest of standards and by experts regarded as the best amino acid manufacturers in the world. Unlike other glutathione products in the market today, KB glutathione with NAC was manufactured without compromising its quality just to be able to sell it at the prevailing market price. Each KB pack also comes with Pure Rosehips Vitamin C to further complement the KB efficiency. Each Rosehips Vitamin C capsule is in its purely organic form which gives it a natural, timed release quality. Vitamin C is essential in helping both the glutathione and NAC retain more of its active components and at the same time flush out some of the glutathione and NAC which may be oxidized and become insoluble in the process. KB is undoubtedly the only effective and relevant oral glutathione sold in the market today. Stop wasting your time and money on other glutathione supplements that will never deliver their promised results. Kyusoku Bihaku 500mg Glutathione with NAC and Pure Rosehips Vitamin C is the only oral glutathione supplement you truly deserve. It is the next best thing and the most cost-effective alternative to IV glutathione. With each KB pack, you will get all the results you want without any questions. Now you have been TRULY enlightened.

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